Therefore, it has been suggested that CBD may indirectly enhance anti-inflammatory effects. Instead, CBD offers soothing and pain-reducing effects without the negative side effects associated with THC. This is why CBD is having an undeniable impact on the medical community. In the past two years, the medical community has been forced to take a very serious look at cannabis, something that may have seemed ridiculous a few years ago.
Given the rapid change in the legality of cannabis, coupled with the increased appetite for something new and the momentum of unprecedented profit margins, advertising for cannabinoids in general and CBD in particular has gone wild. Concomitant incubation of CBD with the TRPA1 antagonist A967079 but not with the TRPV1 antagonist capsazepine reduced the effects of CBD on calcium and POPO3 absorption. Outside the U.S. In the US, the prescription drug Sativex, which uses CBD as its active ingredient, is approved for muscle spasticity associated with multiple sclerosis and for cancer pain.
Side effects of CBD in humans include diarrhea and fatigue, and most importantly, CBD interacts with other drugs, as it is metabolized by CYP enzymes in the liver, inhibiting the breakdown of other therapeutic compounds14,15. Although research is still in its early stages, people use each again CBD as an alternative treatment for a variety of health conditions, including inflammation. Some CBD manufacturers have come under government scrutiny for far-fetched and indefensible claims, such as that CBD is a panacea for cancer or COVID-19, and it's not. CBD can increase the level of blood thinners and other medications by competing for liver enzymes that break down these drugs. Consequently, for in vivo applications, CBD must be administered in high concentrations to cause beneficial effects, as shown in the treatment of Dravet syndrome13. Until now, pharmaceutical CBD is only approved by the FDA as an adjunctive therapy for the treatment of a special and rare form of epilepsy.
Researchers need to conduct more human studies to fully understand how CBD works and how it can relieve symptoms such as pain and inflammation. CBD oil (cannabidiol) is rapidly becoming the ideal solution for those suffering from chronic pain due to inflammation. Until there is high-quality scientific evidence in humans, it is difficult to make a recommendation for the regular use of CBD in the treatment of chronic pain. However, most human studies have investigated the role of CBD in managing cancer-related pain and treating cancer.