Our understanding of the role of CBD in pain management continues to evolve, and evidence from animal studies has shown that CBD exerts its analgesic effects through its diverse interactions and modulation of the endocannabinoid, inflammatory and nociceptive systems (pain detection). Meanwhile, several countries have approved CBD to treat certain conditions. It approved it for multiple sclerosis and Canada approved it for cancer pain. Ongoing research suggests that CBD oil for pain may help medical conditions, such as arthritis and fibromyalgia, in varying doses.
Some pains may not be treatable with CBD alone, but they can help when combined with THC applications or Western medications. Researchers haven't found much evidence that CBD can offer mental pain relief. However, the placebo effect may help some people experience less pain after taking CBD. Bryan says he believes a combination of THC and CBD together holds the most promise for pain relief.
While many studies have suggested that CBD oil is useful for pain, more research is needed, especially long-term studies with humans. CBD is often affordable compared to other pain management options, such as prescription pain relievers and surgery, and no appointment is required before purchasing CBD. CBD oil holds particular promise due to its lack of intoxicating effects and a possible lower potential for side effects than many other pain relievers. Most clinical studies describe the effectiveness of co-administration of CBD and Δ9-THC, usually at doses of 2.5 mg of CBD and 2.7 mg of Δ9-THC in an oral mucosal spray, with treatment periods ranging from one to several weeks.
Experts do not recommend using CBD oil in children, as there is little research on the effects of CBD oil on a child's developing brain. In a complete Freund's adjuvant-induced monoarthritic knee joint model in rats, transdermal CBD gel applied for 4 days dose-dependently reduced joint swelling, limb posture scores, synovial membrane thickening and pain in animals. Studies have also revealed that CBD binds to other Gi-coupled receptors, namely opioid receptors, μ opioid receptor (MOR) and δ opioid receptor (DOR) with Ki%3D 7000 nM and Ki%3D 10,000 nM, respectively, or Ki%3D 11 nM for D2 receptors with high functional affinity for dopamine. It's ideal for people who need an easy-to-digest CBD product that provides almost immediate relief from symptoms.
of CBD reduced mechanical allodynia and reversed conditional site preference caused by peripheral nerve block in a rat model of incision pain. Researchers found that compared to placebo, Sativex significantly improved participants' pain during movement, pain at rest, and quality of sleep. This result suggests a more beneficial role for Δ9-THC compared to CBD in attenuating pain due to ambiguous results in serum levels of inflammation-related factors. Epidiolex, a drug containing pure CBD, is indicated for the treatment of seizures associated with Lennox Gastaut syndrome, Dravet syndrome or tuberous sclerosis complex in patients over 1 year of age.
In another study, inflammatory pain was induced by carrageenan injection and investigated the effect of cannabidiolic acid (CBDA), CBD and Δ9-THC. People who use CBD oil for arthritis can find relief for their pain, but more human studies are needed to confirm these findings. .